STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hycARegulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence . Also down-regulates expression of the hyf operon (153 aa)    
Predicted Functional Partners:
hycE
Formate hydrogenlyase subunit hyce; Belongs to the complex I 49 kDa subunit family
 
  
 0.962
hycB
Formate hydrogenlyase subunit hycb; Probable electron transfer protein for hydrogenase 3
 
  
 0.957
hycH
Formate hydrogenlyase maturation protein hych; Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form
 
  
 0.949
fhlA
Formate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster)
 
   
 0.938
fdhF
Formate dehydrogenase-h, selenopolypeptide subunit; Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors
   
  
 0.920
hycI
Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3
 
  
 0.896
hycF
Formate hydrogenlyase complex iron-sulfur protein; Probable electron transfer protein for hydrogenase 3
 
  
 0.885
hycG
Formate hydrogenlyase subunit 7; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration
 
  
 0.875
hypA
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase . Mediates transfer of nickel, but not zinc, from the low-affinity metal-binding site in the GTPase domain of HypB to HypA . HypA is involved in maturation of hydrogenase 3. It may partially substitute for the function of HybF and vice versa . May act as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center
  
  
 0.852
hycC
Formate hydrogenlyase subunit hycc; Belongs to the complex I subunit 4 family
 
  
 0.844
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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