STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
hypAInvolved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase . Mediates transfer of nickel, but not zinc, from the low-affinity metal-binding site in the GTPase domain of HypB to HypA . HypA is involved in maturation of hydrogenase 3. It may partially substitute for the function of HybF and vice versa . May act as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center (116 aa)    
Predicted Functional Partners:
hypB
Gtp hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase . Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion In the presence of GDP, nickel, but not zinc, is transferred from the HypB GTPase domain (G-domain) to HypA
 
 
 0.999
hypC
Hydrogenase expression/formation protein hypc; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor HypC delivers iron-bound CO(2) to HypD where reduction to CO probably occurs . In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand Involved in the maturation of the hydrogenase 3 . Also participates in the maturation of hydrogenase 1
  
 0.998
hypD
Fe-(CN)2CO cofactor assembly scaffold protein HypD; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor HypD may act as a scaffold on which the Fe(CN)(2)CO cofactor is formed . In complex with HypC, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand . Required for the formation of all three hydrogenase isoenzymes (Probable)
 
  
 0.997
hypE
Carbamoyl dehydratase, hydrogenases 1,2,3 maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypF, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypE catalyzes the ATP-dependent dehydration of the carboxamido group attached to its C-terminal cysteine to a cyano group . The cyano group is then transferred from HypE to the HypC-HypD complex or the HybG-HypD complex
 
  
 0.997
hypF
Involved in the maturation of [NiFe] hydrogenases . Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases . HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide . In the absence of any other substrate, displays carbamoyl-phosphate phosphatase activity
 
   
 0.979
slyD
Fkbp-type peptidyl prolyl cis-trans isomerase (rotamase); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in [...]
    
 
 0.970
hybG
Hydrogenase expression/formation protein hypc; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor . HybG delivers iron-bound CO(2) to HypD where reduction to CO probably occurs . In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand (By similarity). Involved in the maturation of the hydrogenase 2. Also participates in the maturation of hydrogenase 1
   
 0.933
hycE
Formate hydrogenlyase subunit hyce; Belongs to the complex I 49 kDa subunit family
 
 
 0.931
hycI
Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3
 
  
 0.890
hycA
Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence . Also down-regulates expression of the hyf operon
  
  
 0.852
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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