STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygeAAsp/glu_racemase family protein; Amino-acid racemase able to utilize a broad range of substrates. Highest activity is observed with L-homoserine and D- homoserine. Has tenfold lower activity against L-methionine, L-leucine, L-valine and L-histidine. Has low activity with L-norvaline, L- asparagine, D-methionine, L-aminobutyric acid, L-isoleucine, L-serine, L-norleucine, L-alanine, L-glutamine, LL-diaminopimelic acid and L- phenylalanine. Has no activity against ten L-amino acids (Thr, Glu, Asp, Arg, Lys, Tyr, Trp, Orn, Cit and Aad) . D-amino acids might be used as components of peptido [...] (230 aa)    
Predicted Functional Partners:
ydeM
Putative anaerobic sulfatase maturation enzyme ydem; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family
      
 0.873
kduI
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions
      0.817
lysA
Diaminopimelate decarboxylase, plp-binding; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate
 
      0.758
ycjX
DUF463 family protein, puatative P-loop NTPase; To H.influenzae HI_1637
      
 0.731
araE
Mfs transporter, sp family, arabinose:h+ symporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system)
  
  
 0.696
yafV
2-oxoglutaramate amidase; Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L-glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity)
      
 0.641
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis
      
 0.637
yhfY
annotation not available
      
 0.616
rspB
Putative zinc-binding dehydrogenase rspb; Not known; probable catabolic enzyme
     
 0.609
araG
L-arabinose transport system atp-binding protein; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
      
 0.604
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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