STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yggRPutative PilT family AAA+ ATPase; Putative protein transport. (326 aa)    
Predicted Functional Partners:
gspF
General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
 
  
 0.818
hofC
Assembly protein in type IV pilin biogenesis, transmembrane protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake.
 
  
 0.816
pppA
Bifunctional prepilin leader peptidase/ methylase; A pre-pilin peptidase involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.
 
   
 0.813
hofQ
DNA catabolic putative fimbrial transporter; Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane.
 
  
 0.751
pykA
Pyruvate kinase II, glucose stimulated; Protein involved in glycolysis, fermentation and anaerobic respiration.
    
 
 0.701
gspG
Pseudopilin, cryptic, general secretion pathway; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
 
  
 0.682
gspO
Bifunctional prepilin leader peptidase/ methylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
   
 0.640
yggS
UPF0001 family protein, PLP-binding; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins. Does not have amino acid racemase activity.
       0.620
smf
DNA recombination-mediator A family protein; Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By similarity). Belongs to the DprA/Smf family.
 
   
 0.615
rdgB
dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Can also efficiently hydrolyze 2'- deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP). Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. To a much lesser extent, is als [...]
     
 0.610
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.