node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
mzrA | yggN | b3096 | b2958 | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | DUF2884 family putative periplasmic protein. | 0.529 |
mzrA | yghD | b3096 | b2968 | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. | 0.542 |
mzrA | yidQ | b3096 | b3688 | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | DUF1375 family outer membrane protein; To E.coli YceK. | 0.475 |
mzrA | yqjA | b3096 | b3095 | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | General envelope maintenance protein; May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition. Belongs to the DedA family. | 0.962 |
rseP | yggN | b0176 | b2958 | Inner membrane zinc RIP metalloprotease; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamas [...] | DUF2884 family putative periplasmic protein. | 0.554 |
rseP | ygiM | b0176 | b3055 | Inner membrane zinc RIP metalloprotease; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamas [...] | SH3 domain protein. | 0.526 |
trmI | yggN | b2960 | b2958 | tRNA m(7)G46 methyltransferase, SAM-dependent; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | DUF2884 family putative periplasmic protein. | 0.511 |
yggN | mzrA | b2958 | b3096 | DUF2884 family putative periplasmic protein. | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | 0.529 |
yggN | rseP | b2958 | b0176 | DUF2884 family putative periplasmic protein. | Inner membrane zinc RIP metalloprotease; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamas [...] | 0.554 |
yggN | trmI | b2958 | b2960 | DUF2884 family putative periplasmic protein. | tRNA m(7)G46 methyltransferase, SAM-dependent; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. | 0.511 |
yggN | yghD | b2958 | b2968 | DUF2884 family putative periplasmic protein. | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. | 0.739 |
yggN | ygiM | b2958 | b3055 | DUF2884 family putative periplasmic protein. | SH3 domain protein. | 0.851 |
yggN | yhjJ | b2958 | b3527 | DUF2884 family putative periplasmic protein. | Putative periplasmic M16 family chaperone; Belongs to the peptidase M16 family. | 0.598 |
yggN | yidQ | b2958 | b3688 | DUF2884 family putative periplasmic protein. | DUF1375 family outer membrane protein; To E.coli YceK. | 0.637 |
yggN | yqjA | b2958 | b3095 | DUF2884 family putative periplasmic protein. | General envelope maintenance protein; May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition. Belongs to the DedA family. | 0.510 |
yggN | yraP | b2958 | b3150 | DUF2884 family putative periplasmic protein. | Outer membrane lipoprotein; Putative periplasmic protein. | 0.558 |
yggN | ytfJ | b2958 | b4216 | DUF2884 family putative periplasmic protein. | Putative transcriptional regulator. | 0.600 |
yghD | mzrA | b2968 | b3096 | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. | Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. | 0.542 |
yghD | yggN | b2968 | b2958 | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. | DUF2884 family putative periplasmic protein. | 0.739 |
yghD | ygiM | b2968 | b3055 | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. | SH3 domain protein. | 0.527 |