STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
glcDGlycolate dehydrogenase, putative fad-linked subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate . Is required for E.coli to grow on glycolate as a sole source of carbon . Is also able to oxidize D-lactate ((R)-lactate) with a similar rate . Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown (499 aa)    
Predicted Functional Partners:
glcF
Glycolate oxidase iron-sulfur subunit; Enzyme; Central intermediary metabolism: Pool, multipurpose conversions
 
 0.999
glcE
Glycolate dehydrogenase, putative fad-binding subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate . Is required for E.coli to grow on glycolate as a sole source of carbon . Is also able to oxidize D-lactate ((R)-lactate) with a similar rate . Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown
 
 0.999
glcB
Malate synthase g; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA
 
 
 0.997
glcG
Putative heme-binding protein glcg; Belongs to the GlcG family
 
  
 0.993
aldA
Lactaldehyde dehydrogenase / glycolaldehyde dehydrogenase; Acts on lactaldehyde as well as other aldehydes
   
 
 0.961
ghrA
Glyoxylate/hydroxypyruvate reductase a; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate. Only D- and L-glycerate are involved in the oxidative activity with NADP. Activity with NAD is very low
    
 0.957
aceB
Malate synthase A; Protein involved in glyoxylate cycle
    
 0.949
glcA
Glycolate/lactate:h(+) symporter glca; Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force
  
  
 0.944
glcC
Gntr family transcriptional regulator, glc operon transcriptional activator; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity Also negatively regulates the transcription of its own gene . Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector
 
  
 0.938
gcl
Tartronate-semialdehyde synthase; Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)
     
 0.933
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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