STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
glcCGntr family transcriptional regulator, glc operon transcriptional activator; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity Also negatively regulates the transcription of its own gene . Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector (254 aa)    
Predicted Functional Partners:
glcG
Putative heme-binding protein glcg; Belongs to the GlcG family
 
   
 0.965
glcB
Malate synthase g; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA
 
  
 0.945
glcD
Glycolate dehydrogenase, putative fad-linked subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate . Is required for E.coli to grow on glycolate as a sole source of carbon . Is also able to oxidize D-lactate ((R)-lactate) with a similar rate . Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown
 
  
 0.938
glcF
Glycolate oxidase iron-sulfur subunit; Enzyme; Central intermediary metabolism: Pool, multipurpose conversions
 
  
 0.901
glcA
Glycolate/lactate:h(+) symporter glca; Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force
     
 0.863
glcE
Glycolate dehydrogenase, putative fad-binding subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate . Is required for E.coli to grow on glycolate as a sole source of carbon . Is also able to oxidize D-lactate ((R)-lactate) with a similar rate . Does not link directly to O(2), and 2,6-dichloroindophenol (DCIP) and phenazine methosulfate (PMS) can act as artificial electron acceptors in vitro, but the physiological molecule that functions as primary electron acceptor during glycolate oxidation is unknown
 
  
 0.860
hcaR
Lysr family transcriptional regulator, hca operon transcriptional activator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism
   
  
 0.830
mhpR
Iclr family transcriptional regulator, mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway
   
  
 0.751
ydcI
Putative dna-binding transcriptional repressor ydci; Belongs to the LysR transcriptional regulatory family
   
    0.640
feaR
Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism
   
  
 0.602
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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