node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hyaB | hyaC | b0973 | b0974 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | 0.999 |
hyaB | hybA | b0973 | b2996 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2 4Fe-4S ferredoxin-type component; Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover. | 0.801 |
hyaB | hybB | b0973 | b2995 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Putative hydrogenase 2 cytochrome b type component; Probable b-type cytochrome; Belongs to the NrfD family. | 0.937 |
hyaB | hybC | b0973 | b2994 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.917 |
hyaB | hybD | b0973 | b2993 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Maturation protease for hydrogenase 2; Protease involved in the C-terminal processing of HybC, the large subunit of hydrogenase 2. Specifically cleaves off a 15 amino acid peptide from the C-terminus of the precursor of HybC; Belongs to the peptidase A31 family. | 0.963 |
hyaB | hybE | b0973 | b2992 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2-specific chaperone; Member of hyb operon. | 0.631 |
hyaB | hybF | b0973 | b2991 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Protein involved with the maturation of hydrogenases 1 and 2; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. HybF is involved in maturation of hydrogenases 1 and 2. It may partially substitute for the function of HypA and vice versa. | 0.861 |
hyaB | hybG | b0973 | b2990 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2 accessory protein; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron-bound CO(2) to HypD where reduction to CO probably occurs. In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand (By similarity). Involved in the maturation of the hydrogenase 2. Also participates in the maturation of hydrogenase 1. | 0.917 |
hyaB | hybO | b0973 | b2997 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Hydrogenase 2, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. | 0.999 |
hyaB | hypF | b0973 | b2712 | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | Carbamoyl phosphate phosphatase and [NiFe] hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. In the absence of any other substrate, displays carbamoyl-phosphate phosphatase activity. | 0.916 |
hyaC | hyaB | b0974 | b0973 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.999 |
hyaC | hybA | b0974 | b2996 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Hydrogenase 2 4Fe-4S ferredoxin-type component; Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover. | 0.721 |
hyaC | hybB | b0974 | b2995 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Putative hydrogenase 2 cytochrome b type component; Probable b-type cytochrome; Belongs to the NrfD family. | 0.780 |
hyaC | hybC | b0974 | b2994 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Hydrogenase 2, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.976 |
hyaC | hybD | b0974 | b2993 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Maturation protease for hydrogenase 2; Protease involved in the C-terminal processing of HybC, the large subunit of hydrogenase 2. Specifically cleaves off a 15 amino acid peptide from the C-terminus of the precursor of HybC; Belongs to the peptidase A31 family. | 0.873 |
hyaC | hybE | b0974 | b2992 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Hydrogenase 2-specific chaperone; Member of hyb operon. | 0.644 |
hyaC | hybF | b0974 | b2991 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Protein involved with the maturation of hydrogenases 1 and 2; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. HybF is involved in maturation of hydrogenases 1 and 2. It may partially substitute for the function of HypA and vice versa. | 0.618 |
hyaC | hybO | b0974 | b2997 | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | Hydrogenase 2, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. | 0.975 |
hybA | hyaB | b2996 | b0973 | Hydrogenase 2 4Fe-4S ferredoxin-type component; Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover. | Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. | 0.801 |
hybA | hyaC | b2996 | b0974 | Hydrogenase 2 4Fe-4S ferredoxin-type component; Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover. | Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family. | 0.721 |