node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aaeR | yqhC | b3243 | b3010 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.544 |
araC | marA | b0064 | b1531 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.952 |
araC | soxS | b0064 | b4062 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | 0.953 |
araC | yidL | b0064 | b3680 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.524 |
araC | yqhC | b0064 | b3010 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.713 |
dkgA | yeaE | b3012 | b1781 | 2,5-diketo-D-gluconate reductase A; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives; Belongs to the aldo/keto reductase family. | Aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent; Putative an aldehyde reductase. | 0.497 |
dkgA | yqhC | b3012 | b3010 | 2,5-diketo-D-gluconate reductase A; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives; Belongs to the aldo/keto reductase family. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.943 |
dkgA | yqhD | b3012 | b3011 | 2,5-diketo-D-gluconate reductase A; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives; Belongs to the aldo/keto reductase family. | Aldehyde reductase, NADPH-dependent; NADP-dependent ADH activity; Belongs to the iron-containing alcohol dehydrogenase family. | 0.957 |
dkgB | yeaE | b0207 | b1781 | 2,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG); Belongs to the aldo/keto reductase family. | Aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent; Putative an aldehyde reductase. | 0.483 |
dkgB | yqhC | b0207 | b3010 | 2,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG); Belongs to the aldo/keto reductase family. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.610 |
dkgB | yqhD | b0207 | b3011 | 2,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG); Belongs to the aldo/keto reductase family. | Aldehyde reductase, NADPH-dependent; NADP-dependent ADH activity; Belongs to the iron-containing alcohol dehydrogenase family. | 0.605 |
marA | araC | b1531 | b0064 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.952 |
marA | yidL | b1531 | b3680 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.720 |
marA | yqhC | b1531 | b3010 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.555 |
nemR | yqhC | b1649 | b3010 | Transcriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.576 |
soxS | araC | b4062 | b0064 | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.953 |
soxS | yidL | b4062 | b3680 | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.734 |
soxS | yqhC | b4062 | b3010 | Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. | Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.638 |
yeaE | dkgA | b1781 | b3012 | Aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent; Putative an aldehyde reductase. | 2,5-diketo-D-gluconate reductase A; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives; Belongs to the aldo/keto reductase family. | 0.497 |
yeaE | dkgB | b1781 | b0207 | Aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent; Putative an aldehyde reductase. | 2,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG); Belongs to the aldo/keto reductase family. | 0.483 |