STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygiD4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. (262 aa)    
Predicted Functional Partners:
yqgA
DUF554 family putative inner membrane protein; Putative transport protein.
      
 0.891
yhhW
Quercetinase activity in vitro; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin.
 
  
 0.820
yhaK
Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family.
 
  
 0.791
aaeX
DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family.
      
 0.786
ybiJ
DUF1471 family putative periplasmic protein.
   
  
 0.740
bssS
Biofilm regulator; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway.
      
 0.736
zupT
Zinc transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions; Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
 
    0.605
ydcO
BenE family inner membrane putative transporter; Putative membrane transport protein.
      
 0.598
yqjF
Putative quinol oxidase subunit.
  
  
 0.595
yhaJ
LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity).
      
 0.552
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.