STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ygiD4,5-DOPA dioxygenase extradiol; In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown (262 aa)    
Predicted Functional Partners:
yhhW
Quercetin 2,3-dioxygenase; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin
 
  
 0.959
yhaK
Pirin-like protein YhaK; Does not have quercetin 2,3-dioxygenase activity; Belongs to the pirin family
 
  
 0.954
yhaJ
Probable HTH-type transcriptional regulator YhaJ; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity)
     
 0.925
yqjF
annotation not available
     
 0.843
ybiJ
annotation not available
      
 0.835
bssS
Biofilm regulator BssS; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway
      
 0.680
zupT
Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions
       0.574
yhaO
Probable serine transporter; Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity); Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily
      
 0.422
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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