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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ebgAEvolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme (1030 aa)    
Predicted Functional Partners:
ebgC
DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known
 
 
 0.999
ygjI
Inner membrane transporter YgjI; Putative oxidoreductase
 
  
 0.989
ebgR
Laci family transcriptional regulator, ebg operon repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer
 
   
 0.971
galM
Galactose-1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose
 
 
 0.939
melA
Alpha-galactosidase, nad(p)-binding; Belongs to the glycosyl hydrolase 4 family
  
  
 0.935
lacZ
Beta-d-galactosidase; Belongs to the glycosyl hydrolase 2 family
  
  
0.928
yihR
Putative sulphoquinovose mutarotase; Uncharacterized protein YihR; Putative aldose-1-epimerase
  
 
 0.908
glk
Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate
     
  0.900
ygjK
Glycoside hydrolase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose
 
 
  0.834
xylA
D-xylose isomerase; Belongs to the xylose isomerase family
    
 0.829
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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