ebgA protein (Escherichia coli K12 MG1655) - STRING interaction network

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Score

ebgA

Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme (1030 aa)

Predicted Functional Partners:

ebgC

0.999

ygjI

0.989

ebgR

0.971

galM

0.939

melA

0.935

lacZ

0.928

yihR

0.908

glk

0.900

ygjK

0.834

xylA

0.829

Your Current Organism:

Escherichia coli K12 MG1655

NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ebgA	ebgC	b3076	b3077	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	0.999
ebgA	ebgR	b3076	b3075	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Laci family transcriptional regulator, ebg operon repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer	0.971
ebgA	galM	b3076	b0756	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Galactose-1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose	0.939
ebgA	glk	b3076	b2388	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate	0.900
ebgA	lacZ	b3076	b0344	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Beta-d-galactosidase; Belongs to the glycosyl hydrolase 2 family	0.928
ebgA	melA	b3076	b4119	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Alpha-galactosidase, nad(p)-binding; Belongs to the glycosyl hydrolase 4 family	0.935
ebgA	xylA	b3076	b3565	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	D-xylose isomerase; Belongs to the xylose isomerase family	0.829
ebgA	ygjI	b3076	b3078	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Inner membrane transporter YgjI; Putative oxidoreductase	0.989
ebgA	ygjK	b3076	b3080	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Glycoside hydrolase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose	0.834
ebgA	yihR	b3076	b3879	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	Putative sulphoquinovose mutarotase; Uncharacterized protein YihR; Putative aldose-1-epimerase	0.908
ebgC	ebgA	b3077	b3076	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Evolved beta-d-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme	0.999
ebgC	ebgR	b3077	b3075	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Laci family transcriptional regulator, ebg operon repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer	0.945
ebgC	galM	b3077	b0756	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Galactose-1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose	0.911
ebgC	glk	b3077	b2388	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate	0.900
ebgC	lacZ	b3077	b0344	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Beta-d-galactosidase; Belongs to the glycosyl hydrolase 2 family	0.926
ebgC	melA	b3077	b4119	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Alpha-galactosidase, nad(p)-binding; Belongs to the glycosyl hydrolase 4 family	0.902
ebgC	xylA	b3077	b3565	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	D-xylose isomerase; Belongs to the xylose isomerase family	0.800
ebgC	ygjI	b3077	b3078	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Inner membrane transporter YgjI; Putative oxidoreductase	0.990
ebgC	ygjK	b3077	b3080	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Glycoside hydrolase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose	0.864
ebgC	yihR	b3077	b3879	DUF386 domain-containing evolved beta-D-galactosidase subunit beta; Required for full activity of the EbgA enzyme. Exact function not known	Putative sulphoquinovose mutarotase; Uncharacterized protein YihR; Putative aldose-1-epimerase	0.900

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