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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
exuTMfs transporter, acs family, hexuronate transporter; Aldohexuronate transport system (432 aa)    
Predicted Functional Partners:
exuR
Gntr family transcriptional regulator, hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers
 
   
 0.974
uxaC
D-glucoronate/d-galacturonate isomerase; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family
 
  
 0.954
uxaA
D-altronate dehydratase; Catalyzes the dehydration of D-altronate
 
  
 0.945
uxaB
Altronate oxidoreductase, nad-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process
 
  
 0.930
uxuA
D-mannonate dehydratase; Catalyzes the dehydration of D-mannonate
  
 
 0.910
uxuR
Gntr family transcriptional regulator, uxu operon transcriptional repressor; Repressor for the uxuRBA operon
 
  
 0.823
uxuB
D-mannonate oxidoreductase, nad-dependent; Belongs to the mannitol dehydrogenase family. UxuB subfamily
 
  
 0.800
garD
D-galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate
 
  
 0.743
kduD
Putative 2-keto-3-deoxy-d-gluconate dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH . To a lesser extent, can also reduce 5-keto- D-gluconate and oxidize D-gluconate and 1,2-propanediol . Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these con [...]
 
 
 0.721
kdgR
Iclr family transcriptional regulator, kdg regulon repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease
  
  
 0.711
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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