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STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
tdcCL-threonine/l-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (443 aa)    
Predicted Functional Partners:
L-threonine dehydratase, catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine t [...]
Lysr family transcriptional regulator, tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon
Propionate kinase/acetate kinase c, anaerobic; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor
Sodium:serine/threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4; Catalyzes the cleavage of 2-ketobutyrate to propionyl-CoA and formate. It can also use pyruvate as substrate
2-iminobutanoate/2-iminopropanoate deaminase; May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2- ketobutyrate
annotation not available
Proton-dependent oligopeptide transporter, pot family; Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate
DUF24 family HxlR-type putative transcriptional regulator; Uncharacterized HTH-type transcriptional regulator YtfH; Protein involved in regulation of transcription, DNA-dependent
D-hexose-6-phosphate epimerase-like protein; Putative glucose-6-phosphate 1-epimerase; Putative enzyme; Central intermediary metabolism: Pool, multipurpose conversions; Belongs to the glucose-6-phosphate 1-epimerase family
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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