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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdcRL-threonine dehydratase operon activator protein; Probable trans-acting positive activator for the tdc operon (72 aa)    
Predicted Functional Partners:
tdcA
Lysr family transcriptional regulator, tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon
  
  
 0.955
yeiL
Crp/fnr family transcriptional regulator, putaive post-exponential-phase nitrogen-starvation regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth
      
 0.576
tdcC
L-threonine/l-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system)
     
 0.561
idnR
Laci family transcriptional regulator, gluconate utilization system gnt-ii transcriptional activator; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate
      
 0.561
yhaB
annotation not available
  
    0.544
yhaC
annotation not available
  
    0.506
tdcB
L-threonine dehydratase, catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine t [...]
     
 0.498
feaR
Arac family transcriptional regulator, positive regulator of tyna and feab; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism
      
 0.474
fnr
Crp/fnr family transcriptional regulator, anaerobic regulatory protein; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration
      
 0.424
feaB
Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde
      
 0.424
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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