node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
diaA | dnaA | b3149 | b3702 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA- ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring onl [...] | 0.966 |
diaA | gmhB | b3149 | b0200 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. | 0.982 |
diaA | hda | b3149 | b2496 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | ATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. | 0.874 |
diaA | hisB | b3149 | b2022 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Protein involved in histidine biosynthetic process. | 0.781 |
diaA | hldE | b3149 | b3052 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | Heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.939 |
diaA | lpoA | b3149 | b3147 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. | 0.900 |
diaA | waaF | b3149 | b3620 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | ADP-heptose--lps heptosyltransferase II; lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosynthetic process. | 0.735 |
diaA | waaQ | b3149 | b3632 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | Lipopolysaccharide core biosynthesis protein; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core (By similarity); Belongs to the glycosyltransferase 9 family. | 0.741 |
diaA | yraN | b3149 | b3148 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | UPF0102 family protein; Belongs to the UPF0102 family. | 0.871 |
diaA | yraP | b3149 | b3150 | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | Outer membrane lipoprotein; Putative periplasmic protein. | 0.945 |
dnaA | diaA | b3702 | b3149 | Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA- ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring onl [...] | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | 0.966 |
dnaA | hda | b3702 | b2496 | Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA- ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring onl [...] | ATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. | 0.962 |
gmhB | diaA | b0200 | b3149 | D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | 0.982 |
gmhB | hldE | b0200 | b3052 | D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. | Heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.998 |
gmhB | waaF | b0200 | b3620 | D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. | ADP-heptose--lps heptosyltransferase II; lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosynthetic process. | 0.995 |
gmhB | waaQ | b0200 | b3632 | D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. | Lipopolysaccharide core biosynthesis protein; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core (By similarity); Belongs to the glycosyltransferase 9 family. | 0.827 |
hda | diaA | b2496 | b3149 | ATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | 0.874 |
hda | dnaA | b2496 | b3702 | ATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. | Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA- ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring onl [...] | 0.962 |
hisB | diaA | b2022 | b3149 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Protein involved in histidine biosynthetic process. | DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. | 0.781 |
hisB | hldE | b2022 | b3052 | Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Protein involved in histidine biosynthetic process. | Heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.411 |