STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ibaGAcid stress protein ibag; Involved in cell resistance against acid stress (84 aa)    
Predicted Functional Partners:
mlaD
Phospholipid/cholesterol/gamma-hch transport system substrate-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane . MlaD functions in substrate binding with strong affinity for phospholipids and modulates ATP hydrolytic activity of the complex
 
  
 0.958
murA
Udp-n-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation . Adds enolpyruvyl to UDP-N-acetylglucosamine . Target for the antibiotic fosfomycin
  
  
 0.926
mlaE
Abc transporter maintaining om lipid asymmetry, inner membrane permease protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane
 
  
 0.904
bolA
Bola family transcriptional regulator, general stress-responsive regulator; Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growth and cell division. Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB. Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions. Essential for normal cell morphology in stationary phase and under conditions of starvation Also regulates a [...]
  
  
 0.877
grxD
Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters
 
   
 0.873
mlaB
Abc transporter maintaining om lipid asymmetry, cytoplasmic stas component; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane . MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability
 
  
 0.867
grxA
Glutaredoxin 1, redox coenzyme for ribonucleotide reductase (rnr1a); The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase
  
   
 0.845
mlaF
Phospholipid/cholesterol/gamma-hch transport system atp-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Responsible for energy coupling to the transport system
 
  
 0.820
mlaC
Abc transporter maintaining om lipid asymmetry, periplasmic binding protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane
 
  
 0.819
yrbG
Putative calcium/sodium:proton antiporter; Inner membrane protein YrbG; Protein involved in calcium:sodium antiporter activity
     
 0.762
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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