Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
query proteins and first shell of interactors
second shell of interactors
proteins of unknown 3D structure
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
|yrbL||annotation not available (210 aa)|| |
Predicted Functional Partners:
PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol.
| || ||0.844
Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
| || || || ||0.807
Mediates magnesium influx to the cytosol.
| || || || ||0.779
Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. PhoP-regulated transcription is redox- sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway; the 2 periplasmic Cys residues of MgrB are required for its action on PhoQ, and thus PhoP.
| || || || || || || ||0.706
Belongs to the glycosyltransferase 8 family
| || || || || || ||0.706
annotation not available
| || || || || || || ||0.701
Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals
| || || ||0.699
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core
| || || || ||0.691
Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP- repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By [...]
| || || || ||0.685
May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors
| || || || ||0.684
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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