node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
murQ | nagA | b2428 | b0677 | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | 0.997 |
murQ | nagB | b2428 | b0678 | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | 0.630 |
murQ | nagE | b2428 | b0679 | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.969 |
murQ | nagK | b2428 | b1119 | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Has also low level glucokinase activity in vitro. Belongs to the ROK (NagC/XylR) family. NagK subfamily. | 0.948 |
murQ | nanE | b2428 | b3223 | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | Putative N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.932 |
nagA | murQ | b0677 | b2428 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.997 |
nagA | nagB | b0677 | b0678 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | 0.999 |
nagA | nagE | b0677 | b0679 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.996 |
nagA | nagK | b0677 | b1119 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Has also low level glucokinase activity in vitro. Belongs to the ROK (NagC/XylR) family. NagK subfamily. | 0.978 |
nagA | nanA | b0677 | b3225 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily. | 0.762 |
nagA | nanE | b0677 | b3223 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Putative N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.990 |
nagA | nanK | b0677 | b3222 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | N-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. Has also low level glucokinase activity in vitro. Belongs to the ROK (NagC/XylR) family. NanK subfamily. | 0.850 |
nagA | nanR | b0677 | b3226 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region. | 0.606 |
nagA | nanT | b0677 | b3224 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | Sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N- glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D- galactonononic acid (KDN). Functions as a bidirectional transporter in vitro. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. | 0.786 |
nagA | yhcH | b0677 | b3221 | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | DUF386 family protein, cupin superfamily. | 0.541 |
nagB | murQ | b0678 | b2428 | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. | 0.630 |
nagB | nagA | b0678 | b0677 | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D- glucosamine-6-phosphate, N-acetyl-D-glucosamine-6-sulfate, N-acetyl-D- galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. | 0.999 |
nagB | nagE | b0678 | b0679 | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. It can also transport and phosphorylate the antibiotic streptozotocin. Could play a significant role in the recycling of peptidoglycan. | 0.973 |
nagB | nanA | b0678 | b3225 | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily. | 0.826 |
nagB | nanE | b0678 | b3223 | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. | Putative N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). | 0.986 |