node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aaeA | aaeB | b3241 | b3240 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | 0.999 |
aaeA | aaeR | b3241 | b3243 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | 0.787 |
aaeA | aaeX | b3241 | b3242 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. | 0.942 |
aaeA | emrB | b3241 | b2686 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Multidrug efflux system protein; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. | 0.570 |
aaeA | emrY | b3241 | b2367 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Putative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. | 0.614 |
aaeA | macB | b3241 | b0879 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Macrolide ABC transporter peremase/ATPase; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid. Belongs to the ABC transporter superfamily. Macrolide exporte [...] | 0.708 |
aaeA | tolC | b3241 | b3035 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.557 |
aaeA | ydhK | b3241 | b1645 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Putative efflux protein (PET) component of YdhJK efflux pump. | 0.586 |
aaeA | yeeZ | b3241 | b2016 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Putative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process. | 0.653 |
aaeA | yhcO | b3241 | b3239 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | Putative barnase inhibitor; Belongs to the barstar family. | 0.539 |
aaeB | aaeA | b3240 | b3241 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | 0.999 |
aaeB | aaeR | b3240 | b3243 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | 0.807 |
aaeB | aaeX | b3240 | b3242 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. | 0.898 |
aaeB | yhcO | b3240 | b3239 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Putative barnase inhibitor; Belongs to the barstar family. | 0.539 |
aaeR | aaeA | b3243 | b3241 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | 0.787 |
aaeR | aaeB | b3243 | b3240 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | 0.807 |
aaeR | aaeX | b3243 | b3242 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. | 0.772 |
aaeR | tolC | b3243 | b3035 | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. | Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. | 0.460 |
aaeX | aaeA | b3242 | b3241 | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. | 0.942 |
aaeX | aaeB | b3242 | b3240 | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | 0.898 |