STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aaeXDUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. (67 aa)    
Predicted Functional Partners:
aaeA
P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB.
  
  
 0.942
aaeB
P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate.
  
  
 0.898
yqgA
DUF554 family putative inner membrane protein; Putative transport protein.
   
  
 0.809
ygiD
4,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown.
      
 0.786
aaeR
Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon.
  
  
 0.772
yhcO
Putative barnase inhibitor; Belongs to the barstar family.
       0.539
bssS
Biofilm regulator; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway.
      
 0.454
emrY
Putative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
      
 0.426
yhiI
Putative membrane fusion protein (MFP) of efflux pump; Putative membrane protein.
      
 0.407
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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