node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aaeB | ampE | b3240 | b0111 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | 0.647 |
aaeB | lptC | b3240 | b3199 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Periplasmic membrane-anchored LPS-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.433 |
aaeB | sseB | b3240 | b2522 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Rhodanase-like enzyme, sulfur transfer from thiosulfate; May be involved in the enhancement of serine-sensitivity. | 0.640 |
aaeB | tsgA | b3240 | b3364 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Putative transport; Belongs to the major facilitator superfamily. TsgA family. | 0.721 |
aaeB | yeeA | b3240 | b2008 | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | Putative transporter, FUSC family inner membrane protein. | 0.560 |
agp | ccmD | b1002 | b2198 | Glucose-1-phosphatase/inositol phosphatase; Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source; Belongs to the histidine acid phosphatase family. | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.541 |
agp | csrD | b1002 | b3252 | Glucose-1-phosphatase/inositol phosphatase; Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source; Belongs to the histidine acid phosphatase family. | Targeting factor for csrBC sRNA degradation; Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di-GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression. | 0.664 |
agp | tsgA | b1002 | b3364 | Glucose-1-phosphatase/inositol phosphatase; Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source; Belongs to the histidine acid phosphatase family. | Putative transport; Belongs to the major facilitator superfamily. TsgA family. | 0.616 |
ampE | aaeB | b0111 | b3240 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. | 0.647 |
ampE | ccmD | b0111 | b2198 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | 0.417 |
ampE | lptC | b0111 | b3199 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Periplasmic membrane-anchored LPS-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.595 |
ampE | sseB | b0111 | b2522 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Rhodanase-like enzyme, sulfur transfer from thiosulfate; May be involved in the enhancement of serine-sensitivity. | 0.635 |
ampE | tsgA | b0111 | b3364 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Putative transport; Belongs to the major facilitator superfamily. TsgA family. | 0.733 |
ampE | yeeA | b0111 | b2008 | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | Putative transporter, FUSC family inner membrane protein. | 0.752 |
appA | csrD | b0980 | b3252 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | Targeting factor for csrBC sRNA degradation; Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di-GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression. | 0.562 |
appA | tsgA | b0980 | b3364 | Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation. | Putative transport; Belongs to the major facilitator superfamily. TsgA family. | 0.592 |
ccmD | agp | b2198 | b1002 | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Glucose-1-phosphatase/inositol phosphatase; Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source; Belongs to the histidine acid phosphatase family. | 0.541 |
ccmD | ampE | b2198 | b0111 | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. | 0.417 |
ccmD | csrD | b2198 | b3252 | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Targeting factor for csrBC sRNA degradation; Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di-GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression. | 0.622 |
ccmD | lptC | b2198 | b3199 | Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. | Periplasmic membrane-anchored LPS-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.541 |