STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hofQDNA catabolic putative fimbrial transporter; Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane. (412 aa)    
Predicted Functional Partners:
hofN
DNA catabolic putative fimbrial assembly protein; Required for the use of extracellular DNA as a nutrient.
  
 
 0.979
hofM
DNA catabolic putative pilus assembly protein; Required for the use of extracellular DNA as a nutrient.
  
 
 0.972
hofC
Assembly protein in type IV pilin biogenesis, transmembrane protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake.
 
 
 0.958
hofB
T2SE secretion family protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake; Belongs to the GSP E family.
 
 
 
 0.946
ppdD
Putative prepilin peptidase-dependent pilin; Not yet known; Belongs to the N-Me-Phe pilin family.
 
  
 0.912
gspM
General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
      
 0.896
alpA
CP4-57 prophage; Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease. Part of the cryptic P4-like prophage CP4-57. Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans- translation.
     
 0.895
hofP
DNA catabolic protein; Required for the use of extracellular DNA as a nutrient.
  
    0.861
hofO
DNA catabolic protein; Required for the use of extracellular DNA as a nutrient.
  
  
 0.809
ycaI
ComEC family inner membrane protein.
      
 0.807
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.