node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
kptA | rtcB | b4331 | b3421 | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | 0.757 |
kptA | rtcR | b4331 | b3422 | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | Sigma 54-dependent transcriptional regulator of rtcba expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 | 0.473 |
kptA | ybiA | b4331 | b0798 | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | Uncharacterized protein; Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose . Is Required for swarming motility | 0.685 |
kptA | yehL | b4331 | b2119 | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | Putative hexameric aaa+ moxr family atpase; Uncharacterized protein YehL; Protein involved in ATP-binding cassette (ABC) transporter activity | 0.690 |
ligT | rtcB | b0147 | b3421 | Rna 2',3'-cyclic 3'-phosphodiesterase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester . In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | 0.648 |
mazF | rtcB | b2782 | b3421 | Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs . Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this removes the anti-Shine-Dalgarno sequence forming [...] | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | 0.605 |
rtcA | rtcB | b4475 | b3421 | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | 0.998 |
rtcA | rtcR | b4475 | b3422 | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | Sigma 54-dependent transcriptional regulator of rtcba expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 | 0.988 |
rtcA | ybiA | b4475 | b0798 | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | Uncharacterized protein; Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose . Is Required for swarming motility | 0.439 |
rtcB | kptA | b3421 | b4331 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | 0.757 |
rtcB | ligT | b3421 | b0147 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Rna 2',3'-cyclic 3'-phosphodiesterase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester . In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible | 0.648 |
rtcB | mazF | b3421 | b2782 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs . Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this removes the anti-Shine-Dalgarno sequence forming [...] | 0.605 |
rtcB | rtcA | b3421 | b4475 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing | 0.998 |
rtcB | rtcR | b3421 | b3422 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Sigma 54-dependent transcriptional regulator of rtcba expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 | 0.989 |
rtcB | sbcC | b3421 | b0397 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Atp dependent, structure specific dna nuclease - sbcc subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity | 0.511 |
rtcB | ybiA | b3421 | b0798 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Uncharacterized protein; Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose . Is Required for swarming motility | 0.530 |
rtcB | yehL | b3421 | b2119 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Putative hexameric aaa+ moxr family atpase; Uncharacterized protein YehL; Protein involved in ATP-binding cassette (ABC) transporter activity | 0.485 |
rtcB | yfbK | b3421 | b2270 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | Von willebrand factor domain putative lipoprotein; To Synechocystis PCC 6803 sll0103 | 0.484 |
rtcB | yhcG | b3421 | b3220 | Trna-splicing ligase rtcb (3'-phosphate/5'-hydroxy nucleic acid ligase); GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases | DUF1016 family protein in the PD-(D/E)XK nuclease superfamily; May be a nuclease involved in DNA recombination and repair | 0.771 |
rtcR | kptA | b3422 | b4331 | Sigma 54-dependent transcriptional regulator of rtcba expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54 | Putative rna 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase | 0.473 |