STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xylHD-xylose transport system permease protein; Part of the binding-protein-dependent transport system for D- xylose. Probably responsible for the translocation of the substrate across the membrane (393 aa)    
Predicted Functional Partners:
xylF
D-xylose transport system substrate-binding protein; Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose
 
 0.999
xylG
D-xylose transport system atp-binding protein; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose
 
 0.999
xylR
Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon
 
   
 0.935
pptA
Putative 4-oxalocrotonate tautomerase (4-ot); Can use enol isomers of phenylpyruvate, 2-hydroxy-2,4- pentadienoate and (p-hydroxyphenyl)pyruvate as substrates
      
 0.876
xylA
D-xylose isomerase; Belongs to the xylose isomerase family
 
  
 0.856
mhpE
4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of 3-phenylpropanoate
      
 0.826
xylB
Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate . Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency . Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates . Has a weak substrate-independent Mg-ATP-hydrolyzing activity
 
  
 0.793
araG
L-arabinose transport system atp-binding protein; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable)
   
 0.764
rbsA
Ribose transport system atp-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system
   
 0.747
lyxK
L-xylulose kinase; Catalyzes the phosphorylation of L-xylulose and 3-keto-L- gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate
     
 0.738
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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