STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
mtlAMannitol-specific PTS enzyme: IIA, IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport. Also able to use D-mannonic acid. (637 aa)    
Predicted Functional Partners:
mtlD
Mannitol-1-phosphate dehydrogenase, NAD-dependent; Mannitol-1-phosphate dehydrogenase; Protein involved in carbohydrate catabolic process.
 
 0.999
ptsH
Phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
   
 0.998
cmtA
Putative mannitol-specific PTS IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
 
 
0.960
cmtB
Putative mannitol-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
 
 
0.960
ydfI
Putative oxidoreductase; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
  
  
 0.922
yeiQ
Putative oxidoreductase; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
  
  
 0.922
uxuB
D-mannonate oxidoreductase, NAD-dependent; D-mannonate oxidoreductase; Protein involved in carbohydrate catabolic process; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
  
  
 0.922
uxaB
Altronate oxidoreductase, NAD-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process.
  
  
 0.921
mtlR
Mannitol operon repressor; Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to belong to a new class of transcription factors in bacteria that may regulate gene expression indirectly, perhaps as a part of a larger transcriptional complex.
  
  
 0.920
mngA
Fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl- D-glycerate transport. Also involved in thermoinduction of ompC.
 
  
0.917
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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