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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
waaLO-antigen ligase; Adds the O-antigen on the glucose group of LPS (419 aa)    
Predicted Functional Partners:
waaC
Adp-heptose:lps heptosyl transferase i; Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA
     
 0.980
waaF
ADP-heptose--lps heptosyltransferase II; lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosynthetic process
     
 0.971
waaU
Putative adp-heptose:lps heptosyltransferase 4; Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS
 
  
 0.964
hldD
ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose
     
 0.936
wzxB
Polyisoprenol-linked o-antigen repeat unit flippase; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units
  
 
 0.925
waaR
Udp-glucose/galactose:(glucosyl)lps alpha-1,2-glucosyl/galactosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS
 
  
 0.925
wzyE
Putative eca polysaccharide chain elongation protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC))
      
 0.917
wzxC
M-antigen undecaprenyl disphosphate flippase; Belongs to the polysaccharide synthase family
   
 
 0.908
wzxE
Enterobacterial common antigen flippase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). Could also mediate the translocation of Und-PP-GlcNAc
   
 
 0.908
wecA
Udp-glcnac:undecaprenyl-phosphate/decaprenyl-phosphate glcnac-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis, and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen lipopolysaccharide (LPS) in many E.coli O types. The apparent affinity of WecA for the polyisoprenyl phosphate substrat [...]
     
 0.904
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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