STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yicRUPF0758 family protein; DNA repair protein; Protein involved in DNA-dependent DNA replication and DNA repair; Belongs to the UPF0758 family. YicR subfamily. (222 aa)    
Predicted Functional Partners:
mutS
Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
 
   
 0.707
gntX
DNA catabolic protein; Required for the use of extracellular DNA as a nutrient. Has been suggested to be involved in gluconate metabolism ; Belongs to the ComF/GntX family.
 
    0.629
yjbT
Putative periplasmic protein; Belongs to the YjbT family.
      
 0.623
yjiM
Putative 2-hydroxyglutaryl-CoA dehydratase; Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
      
 0.621
yegL
VMA domain protein.
  
   
 0.586
mreC
Cell wall structural complex MreBCD transmembrane component MreC; Involved in formation and maintenance of cell shape. Responsible for formation of rod shape. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreC family.
  
  
 0.566
ycaI
ComEC family inner membrane protein.
 
  
 0.535
rpmB
50S ribosomal subunit protein L28; Protein involved in structural constituent of ribosome and translation.
     
 0.535
dfp
Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine. In the C-terminal section; belongs to the PPC synthetase family.
       0.530
dut
Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
       0.530
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.