STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nepIPutative transporter; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine. (396 aa)    
Predicted Functional Partners:
yicN
DUF1198 family protein.
      0.828
ybcI
DUF457 family inner membrane protein.
   
  
 0.736
yeiB
DUF418 family putative inner membrane protein; Involved in transport; To B.subtilis YxaH and YrkO.
   
  
 0.580
ydeE
Putative transporter; A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs to the major facilitator superfamily.
  
  
 0.474
pgrR
Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function.
 
   
 0.466
yjjX
Non-canonical purine NTP phosphatase, ITPase/XTPase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. ITP and XTP are the best substrates, followed by GDP and dITP. Is not active on dATP and dGTP, and exhibits no phosphatase activity toward pyrimidines (CTP, TTP, UTP, dCTP, and dTTP). Seems also implicated in the resistance against the thiamine metabolism inhib [...]
      
 0.457
yicS
Putative periplasmic protein.
      
 0.457
ycaN
Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family.
  
   
 0.447
ydhP
Putative MFS transporter, inner membrane protein; Putative transport protein.
  
  
0.433
ydeA
Arabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
  
  
0.421
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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