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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ivbLIlvbn operon leader peptide; This protein is involved in control of the biosynthesis of isoleucine, leucine, and valine (32 aa)    
Predicted Functional Partners:
ilvB
Acetolactate synthase I,valine-sensitive, large subunit; Belongs to the TPP enzyme family
  
  
 0.869
ilvL
Ilvxgmeda operon leader peptide; ilvGEDA operon leader peptide
   
  
 0.823
ilvN
Belongs to the acetolactate synthase small subunit family
  
    0.613
leuL
Leu operon leader peptide; Involved in control of the biosynthesis of leucine
      
 0.603
yebW
annotation not available
      
 0.485
uhpC
Mfs transporter, opa family, sugar phosphate sensor protein uhpc; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB
       0.430
uhpB
Sensory histidine kinase in two-component regulatory sytem with uhpa; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA Can also dephosphorylate UhpA
       0.430
uhpA
Two-component system, narl family, uhpt operon response regulator uhpa; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region
       0.430
artM
L-arginine abc transporter membrane subunit artm; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane
      
 0.422
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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