STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hsrAPutative multidrug or homocysteine efflux system; Belongs to the major facilitator superfamily. EmrB family (475 aa)    
Predicted Functional Partners:
yieP
annotation not available
 
    0.831
nikR
Copg family transcriptional regulator, nickel-responsive regulator; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel
      
 0.604
glxR
Tartronate semialdehyde reductase, nadh-dependent; Belongs to the HIBADH-related family
   
 
 0.595
emrA
Multidrug efflux pump membrane fusion protein emra; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC
  
   
 0.563
emrK
Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs
  
   
 0.561
pepN
Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation
    
 0.522
qorA
Quinone oxidoreductase, nadph-dependent; Quinone oxidoreductase; Protein involved in electron carrier activity
   
  
 0.488
hpf
Ribosome hibernation promoting factor hpf; During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes . Converts immature 90S particles formed by RMF into 100S ribosomes . Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; however RMF is still able to bind . In this crystal binding of HPF induces movement of the 30S [...]
      
 0.480
arsR
Arsr family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity)
   
  
 0.431
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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