node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
araC | marA | b0064 | b1531 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.952 |
araC | melR | b0064 | b4118 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | 0.945 |
araC | rhaR | b0064 | b3906 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | 0.565 |
araC | rhaS | b0064 | b3905 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Transcriptional activator of rhaBAD and rhaT; Activates expression of the rhaBAD and rhaT operons. | 0.793 |
araC | rhaT | b0064 | b3907 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | L-rhamnose:proton symporter; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, but at reduced rates. | 0.462 |
araC | rob | b0064 | b4396 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. | 0.874 |
araC | rpoD | b0064 | b3067 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB. Belongs to the sigma-70 factor family. RpoD/SigA subfamily. | 0.871 |
araC | yidL | b0064 | b3680 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.524 |
marA | araC | b1531 | b0064 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.952 |
marA | melR | b1531 | b4118 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | 0.730 |
marA | rhaR | b1531 | b3906 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | 0.809 |
marA | rhaS | b1531 | b3905 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Transcriptional activator of rhaBAD and rhaT; Activates expression of the rhaBAD and rhaT operons. | 0.761 |
marA | yidL | b1531 | b3680 | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.720 |
melR | araC | b4118 | b0064 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.945 |
melR | marA | b4118 | b1531 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. | 0.730 |
melR | rhaR | b4118 | b3906 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. | 0.934 |
melR | rhaS | b4118 | b3905 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Transcriptional activator of rhaBAD and rhaT; Activates expression of the rhaBAD and rhaT operons. | 0.899 |
melR | rob | b4118 | b4396 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. | 0.609 |
melR | rpoD | b4118 | b3067 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB. Belongs to the sigma-70 factor family. RpoD/SigA subfamily. | 0.568 |
melR | yidL | b4118 | b3680 | Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. | 0.666 |