| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| argR | fadR | b3237 | b1187 | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1 | Gntr family transcriptional regulator, negative regulator for fad regulon and positive regulator of faba; Multifunctional regulator of fatty acid metabolism Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE . Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes | 0.771 |
| argR | metJ | b3237 | b3938 | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1 | Metj family transcriptional regulator, methionine regulon repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated | 0.926 |
| argR | metR | b3237 | b3828 | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1 | Lysr family transcriptional regulator, regulator for mete and meth; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer | 0.483 |
| argR | yejL | b3237 | b2187 | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1 | DUF1414 domain-containing protein YejL; Belongs to the UPF0352 family | 0.605 |
| fadR | argR | b1187 | b3237 | Gntr family transcriptional regulator, negative regulator for fad regulon and positive regulator of faba; Multifunctional regulator of fatty acid metabolism Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE . Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1 | 0.771 |
| fadR | metJ | b1187 | b3938 | Gntr family transcriptional regulator, negative regulator for fad regulon and positive regulator of faba; Multifunctional regulator of fatty acid metabolism Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE . Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes | Metj family transcriptional regulator, methionine regulon repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated | 0.886 |
| fadR | yejL | b1187 | b2187 | Gntr family transcriptional regulator, negative regulator for fad regulon and positive regulator of faba; Multifunctional regulator of fatty acid metabolism Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE . Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes | DUF1414 domain-containing protein YejL; Belongs to the UPF0352 family | 0.742 |
| metA | metB | b4013 | b3939 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | 0.995 |
| metA | metC | b4013 | b3008 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | Cystathionine beta-lyase/l-cysteine desulfhydrase; Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis . Also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine . In addition, under certain growth conditions, exhibits significant alanine racemase coactivity | 0.795 |
| metA | metF | b4013 | b3941 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | Methylenetetrahydrofolate reductase (nadph); Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine | 0.853 |
| metA | metJ | b4013 | b3938 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | Metj family transcriptional regulator, methionine regulon repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated | 0.825 |
| metA | metK | b4013 | b2942 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme Is essential for growth | 0.778 |
| metA | metL | b4013 | b3940 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | Bifunctional aspartokinase / homoserine dehydrogenase 2; In the N-terminal section; belongs to the aspartokinase family | 0.987 |
| metA | metR | b4013 | b3828 | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | Lysr family transcriptional regulator, regulator for mete and meth; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer | 0.783 |
| metB | metA | b3939 | b4013 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | Homoserine o-succinyltransferase/o-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine . Cannot use acetyl-CoA | 0.995 |
| metB | metC | b3939 | b3008 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | Cystathionine beta-lyase/l-cysteine desulfhydrase; Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis . Also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine . In addition, under certain growth conditions, exhibits significant alanine racemase coactivity | 0.952 |
| metB | metF | b3939 | b3941 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | Methylenetetrahydrofolate reductase (nadph); Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine | 0.991 |
| metB | metJ | b3939 | b3938 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | Metj family transcriptional regulator, methionine regulon repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated | 0.969 |
| metB | metK | b3939 | b2942 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme Is essential for growth | 0.891 |
| metB | metL | b3939 | b3940 | O-succinylhomoserine(thiol)-lyase/o-succinylhomoserine lyase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia | Bifunctional aspartokinase / homoserine dehydrogenase 2; In the N-terminal section; belongs to the aspartokinase family | 0.998 |
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