STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pepEPeptidase E; Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids; Belongs to the peptidase S51 family (229 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate; Belongs to the GART family
 
     0.769
ynjE
Thiosulfate sulfurtransferase YnjE; Putative thiosulfate sulfur transferase; Protein involved in sulfur metabolic process
   
  
 0.764
nrfB
Cytochrome c-type protein NrfB; Plays a role in nitrite reduction
   
  
 0.713
ynfK
ATP-dependent dethiobiotin synthetase BioD 2; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring; Belongs to the dethiobiotin synthetase family
   
  
 0.623
tabA
Toxin-antitoxin biofilm protein TabA; Influences biofilm formation. Represses fimbria genes in 8 hours biofilms. May act in response to the combined activity of several toxin-antitoxin (TA) systems
      
 0.553
rluF
23S rRNA pseudouridine(2604) synthase; Catalyzes the synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA. Can, to a small extent, also react with uracil-2605
   
   0.547
bioD
ATP-dependent dethiobiotin synthetase BioD 1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Only CTP can partially replace ATP while diaminobiotin is only 37% as effective as 7,8-diaminopelargonic acid; Belongs to the dethiobiotin synthetase family
      
 0.501
grcA
Autonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins
      
 0.488
pepB
Peptidase B; Probably plays an important role in intracellular peptide degradation
    
 
 0.478
alr
Alanine racemase, biosynthetic; Catalyzes the interconversion of L-alanine and D- alanine. Provides the D-alanine required for cell wall biosynthesis
      
 0.469
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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