STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
nrfDPutative menaquinol-cytochrome c reductase subunit nrfd; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes (318 aa)    
Predicted Functional Partners:
nrfC
Putative menaquinol-cytochrome c reductase 4fe-4s subunit; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
 
 
 0.999
nrfA
Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process Has very low activity toward hydroxylamine . Has even lower activity toward sulfite . Sulfite reductase activity is maximal at neutral pH (By similarity)
 
 
 0.998
nrfB
Nitrite reductase, formate-dependent, penta-heme cytochrome c; Plays a role in nitrite reduction
 
  
 0.995
nrfG
Heme lyase (nrfefg) for insertion of heme into c552, subunit nrfg; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes
 
  
 0.960
fdoG
Formate dehydrogenase-o, large subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site
    
 0.934
fdnG
Formate dehydrogenase-n, alpha subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar)
    
 0.926
fdoI
Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase
     
 0.924
fdoH
Formate dehydrogenase iron-sulfur subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity)
    
 0.919
nrfF
Heme lyase (nrfefg) for insertion of heme into c552, subunit nrff; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase
 
  
 0.917
fdnH
Formate dehydrogenase-n, fe-s (beta) subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta subunit FdnH is an electron transfer unit containing 4 iron-sulfur clusters; it serves as a conduit for electrons that are transferred from the formate oxidation site in the alpha subunit (FdnG) to the menaquinone associated with the gamma subunit (FdnI) of formate dehydrogenase-N. Formate dehydrogenase-N is part of a system that generates proton motive force, togethe [...]
    
  0.904
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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