STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrfFFormate-dependent nitrite reductase complex subunit NrfF; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase (127 aa)    
Predicted Functional Partners:
nrfE
Probable cytochrome c-type biogenesis protein NrfE; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase
 
 0.997
nrfG
Formate-dependent nitrite reductase complex subunit NrfG; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes
  
 0.997
nrfB
Cytochrome c-type protein NrfB; Plays a role in nitrite reduction
 
  
 0.949
nrfC
Protein NrfC; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
  
  
 0.949
ccmF
Cytochrome c-type biogenesis protein CcmF; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase
 
 0.935
ccmE
Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family
 
 
 0.877
dsbE
Thiol:disulfide interchange protein DsbE; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD
 
  
 0.866
nrfD
Protein NrfD; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes
 
    0.864
ccmB
Heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
 
  
 0.832
ccmC
Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
 
  
 0.829
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (5%) [HD]