STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dcuAAnaerobic c4-dicarboxylate transporter dcua; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane (433 aa)    
Predicted Functional Partners:
aspA
Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate
 
  
 0.831
dhaR
Dna-binding transcriptional dual regulator dhar; Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own expression
      
 0.781
ubiI
2-octaprenylphenol hydroxylase, FAD-dependent; FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis
      
 0.733
hyaB
Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth
   
  
 0.638
sugE
Quaternary ammonium compound-resistance protein suge; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons . Overexpression leads to resistance to a subset of toxic quaternary ammonium compounds such as cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations
      
 0.627
cutA
Divalent-cation tolerance protein, copper sensitivity; Involved in resistance toward heavy metals
  
    0.594
dsbD
Thiol:disulfide interchange protein and activator of dsbc; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the active site of DsbC, DsbE and DsbG in a reduced state. This transfer involves a cascade of disulfide bond formation and reduction steps
  
    0.581
yidE
Putative transport protein yide; Putative transport protein
 
   
 0.574
ansB
Periplasmic l-asparaginase 2; Belongs to the asparaginase 1 family
 
    0.563
yjdC
Putative dna-binding transcriptional regulator yjdc; HTH-type transcriptional regulator YjdC; Anticodon: GAA
  
  
 0.509
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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