STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aspAAspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate (478 aa)    
Predicted Functional Partners:
ansB
Periplasmic l-asparaginase 2; Belongs to the asparaginase 1 family
 
 0.988
aspC
Aspartate aminotransferase, plp-dependent; Aspartate aminotransferase; Protein involved in cellular amino acid catabolic process and aspartate biosynthetic process
     
 0.959
gltA
Belongs to the citrate synthase family
   
 
 0.957
ansA
Cytoplasmic l-asparaginase 1; Belongs to the asparaginase 1 family
    
 0.945
nadB
Quinolinate synthase, l-aspartate oxidase (b protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate
     
 0.929
asnB
Asparagine synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity
     
 0.921
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
     
 0.921
asnA
Aspartate--ammonia ligase; May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn
     
 0.915
panD
Aspartate 1-decarboxylase proenzyme; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
     
 0.912
dcuB
Anaerobic c4-dicarboxylate transporter dcub; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
 
  
 0.912
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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