node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
frlA | yjeH | b3370 | b4141 | Putative fructoselysine transporter; Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.494 |
groS | yjeH | b4142 | b4141 | Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.514 |
leuE | yahN | b1798 | b0328 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase. | 0.412 |
leuE | yjeH | b1798 | b4141 | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.557 |
metA | metJ | b4013 | b3938 | Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine. Cannot use acetyl-CoA. Belongs to the MetA family. | Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. | 0.863 |
metA | thrA | b4013 | b0002 | Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine. Cannot use acetyl-CoA. Belongs to the MetA family. | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process. | 0.959 |
metA | yjeH | b4013 | b4141 | Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine. Cannot use acetyl-CoA. Belongs to the MetA family. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.781 |
metJ | metA | b3938 | b4013 | Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. | Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine. Cannot use acetyl-CoA. Belongs to the MetA family. | 0.863 |
metJ | thrA | b3938 | b0002 | Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process. | 0.708 |
metJ | yjeH | b3938 | b4141 | Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.530 |
qorB | yjeH | b4211 | b4141 | NAD(P)H:quinone oxidoreductase; Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.606 |
thrA | metA | b0002 | b4013 | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process. | Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O- succinylhomoserine. Cannot use acetyl-CoA. Belongs to the MetA family. | 0.959 |
thrA | metJ | b0002 | b3938 | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process. | Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. | 0.708 |
thrA | yjeH | b0002 | b4141 | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosynthetic process. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.529 |
yahN | leuE | b0328 | b1798 | Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase. | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | 0.412 |
yahN | yjeH | b0328 | b4141 | Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.537 |
ycdZ | yjeH | b1036 | b4141 | DUF1097 family inner membrane protein. | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | 0.490 |
yjeH | frlA | b4141 | b3370 | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | Putative fructoselysine transporter; Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded. | 0.494 |
yjeH | groS | b4141 | b4142 | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.514 |
yjeH | leuE | b4141 | b1798 | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. | 0.557 |