node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
chpB | mazF | b4225 | b2782 | Toxin of the ChpB-ChpS toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB [...] | mRNA interferase toxin, antitoxin is MazE; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs. Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A. Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this remove [...] | 0.737 |
chpB | ytfH | b4225 | b4212 | Toxin of the ChpB-ChpS toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB [...] | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.533 |
cohE | ytfH | b1145 | b4212 | E14 prophage; repressor protein phage e14. | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.510 |
ggt | ytfH | b3447 | b4212 | Gamma-glutamyltranspeptidase; Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases; it may function in amino acid uptake/salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D- gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acce [...] | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.494 |
mazF | chpB | b2782 | b4225 | mRNA interferase toxin, antitoxin is MazE; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs. Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A. Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this remove [...] | Toxin of the ChpB-ChpS toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB [...] | 0.737 |
mazF | ytfH | b2782 | b4212 | mRNA interferase toxin, antitoxin is MazE; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs. Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A. Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this remove [...] | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.520 |
nadR | yjdN | b4390 | b4107 | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | Metalloprotein superfamily protein. | 0.806 |
nadR | ytfH | b4390 | b4212 | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.708 |
pgpC | ytfH | b2560 | b4212 | Phosphatidylglycerophosphatase C, membrane bound; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.461 |
qorB | ytfF | b4211 | b4210 | NAD(P)H:quinone oxidoreductase; Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth. | DMT transporter family inner membrane protein; Putative transmembrane subunit. | 0.556 |
qorB | ytfH | b4211 | b4212 | NAD(P)H:quinone oxidoreductase; Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth. | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.909 |
yjdN | nadR | b4107 | b4390 | Metalloprotein superfamily protein. | Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...] | 0.806 |
yjdN | ytfH | b4107 | b4212 | Metalloprotein superfamily protein. | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.406 |
ynjE | ytfH | b1757 | b4212 | Molybdopterin synthase sulfurtransferase; Putative thiosulfate sulfur transferase; Protein involved in sulfur metabolic process. | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.480 |
ytfF | qorB | b4210 | b4211 | DMT transporter family inner membrane protein; Putative transmembrane subunit. | NAD(P)H:quinone oxidoreductase; Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth. | 0.556 |
ytfF | ytfH | b4210 | b4212 | DMT transporter family inner membrane protein; Putative transmembrane subunit. | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | 0.410 |
ytfH | chpB | b4212 | b4225 | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | Toxin of the ChpB-ChpS toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB [...] | 0.533 |
ytfH | cohE | b4212 | b1145 | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | E14 prophage; repressor protein phage e14. | 0.510 |
ytfH | ggt | b4212 | b3447 | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | Gamma-glutamyltranspeptidase; Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases; it may function in amino acid uptake/salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D- gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acce [...] | 0.494 |
ytfH | mazF | b4212 | b2782 | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. | mRNA interferase toxin, antitoxin is MazE; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single- strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs. Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A. Digests 16S rRNA in vivo 43 nts upstream of the C- terminus; this remove [...] | 0.520 |