STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnRLaci family transcriptional regulator, gluconate utilization system gnt-ii transcriptional activator; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate (332 aa)    
Predicted Functional Partners:
idnK
D-gluconate kinase, thermosensitive; Belongs to the gluconokinase GntK/GntV family
 
  
 0.936
idnD
L-idonate 5-dehydrogenase, nad-binding; Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG)
 
 
 
 0.924
idnT
L-idonate/5-ketogluconate/gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane
  
  
 0.843
idnO
5-keto-D-gluconate 5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD
 
 
 
 0.843
ebgR
Laci family transcriptional regulator, ebg operon repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer
  
   
 0.758
gntT
Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate
     
 0.646
yjgR
DUF853 family protein with NTPase fold; To E.coli YjiB
       0.616
gntK
D-gluconate kinase, thermostable; Belongs to the gluconokinase GntK/GntV family
 
   
 0.598
gntU
Gluconate transporter, low affinity gnt 1 system; Part of the gluconate utilization system Gnt-I; low-affinity intake of gluconate
     
 0.568
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate
 
 
 0.564
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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