STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnRTranscriptional repressor, 5-gluconate-binding; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate. (332 aa)    
Predicted Functional Partners:
idnK
D-gluconate kinase, thermosensitive; Protein involved in carbohydrate catabolic process; Belongs to the gluconokinase GntK/GntV family.
 
  
 0.896
ebgR
Transcriptional repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer.
  
   
 0.878
idnD
L-idonate 5-dehydrogenase, NAD-binding; Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG); Belongs to the zinc-containing alcohol dehydrogenase family.
   
 
 0.876
idnT
L-idonate and D-gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.
  
  
 0.767
idnO
5-keto-D-gluconate-5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
 0.742
gltB
Glutamate synthase, large subunit; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate.
    
 
 0.655
gntT
Gluconate transporter, high-affinity GNT I system; Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate.
      
 0.635
yjgR
DUF853 family protein with NTPase fold; To E.coli YjiB.
       0.561
fryA
Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport.
   
 
 0.514
frwA
Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport.
   
 
 0.514
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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