STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
idnDL-idonate 5-dehydrogenase, nad-binding; Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG) (343 aa)    
Predicted Functional Partners:
idnO
5-keto-D-gluconate 5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD
 
 0.998
idnK
D-gluconate kinase, thermosensitive; Belongs to the gluconokinase GntK/GntV family
  
  
 0.947
ghrB
Glyoxylate/hydroxypyruvate/2-ketogluconate reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D-gluconate (5KDG), 2- keto-D-gluconate (2KDG) to D-gluconate, and 2-keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D- fructose and L-sorbose. Activity with NAD is very low
  
 0.924
idnR
Laci family transcriptional regulator, gluconate utilization system gnt-ii transcriptional activator; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate
 
 
 
 0.924
idnT
L-idonate/5-ketogluconate/gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane
  
  
 0.798
gntT
Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate
      
 0.705
dgoR
Gntr family transcriptional regulator, galactonate operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer
      
 0.607
yiaY
L-threonine dehydrogenase; Probable alcohol dehydrogenase; Putative oxidoreductase
  
  
 0.604
yceB
annotation not available
      
 0.602
cysU
Sulfate/thiosulfate abc transporter inner membrane subunit cysu; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane
      
 0.520
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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