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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fecRAnti-sigma transmembrane signal transducer for ferric citrate transport; Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm (317 aa)    
Predicted Functional Partners:
fecA
Tonb-dependent outer membrane ferric citrate transporter and signal transducer; FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system
 
 
 0.999
fecI
Rna polymerase sigma-19 factor, fec operon-specific; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable)
 
 0.999
fecB
Ferric citrate abc transporter periplasmic binding protein; Binds citrate-dependent Fe(3+); part of the binding-protein- dependent transport system for uptake of citrate-dependent Fe(3+)
 
  
 0.971
fecC
Ferric citrate abc transporter membrane subunit fecc; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
 
  
 0.866
fecE
Ferric citrate transport system atp-binding protein; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
 
   
 0.826
fecD
Ferric citrate abc transporter membrane subunit fecd; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
 
  
 0.815
fhuE
Outer-membrane receptor for ferric coprogen and ferric-rhodotorulic acid; Required for the uptake of Fe(3+) via coprogen, ferrioxamine B, and rhodotorulic acid
 
 
 0.786
exbB
Membrane spanning protein in tonb-exbb-exbd complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB
   
  
 0.754
exbD
Membrane spanning protein in tonb-exbb-exbd complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates
   
  
 0.746
yecH
annotation not available
      
 0.605
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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