STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lgoRPutative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source. (304 aa)    
Predicted Functional Partners:
lgoD
L-galactonate oxidoreductase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate.
 
  
 0.938
nadR
Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity [...]
   
  
 0.933
uxuR
Fructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon.
  
  
 0.910
exuR
Hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.
 
  
 0.902
lgoT
Putative L-galactonate:H+ symporter; Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L- galactonate as the sole carbon source; Belongs to the major facilitator superfamily. Phthalate permease family.
 
  
 0.766
ycfT
Inner membrane protein.
  
     0.690
uidR
Transcriptional repressor; Repressor for the uidRABC (gusRABC) operon.
   
  
 0.643
frvR
Putative frv operon regulator; Could be involved in the regulation of the transcription of the FRV operon.
 
     0.613
cbrA
Colicin M resistance protein; FAD-binding protein, putative oxidoreductase; Belongs to the CbrA family.
  
     0.602
wcaK
Putative galactokinase; Protein involved in colanic acid biosynthetic process.
  
     0.597
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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