STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lgoRGntr family transcriptional regulator, transcriptional activator for l-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source (304 aa)    
Predicted Functional Partners:
lgoD
L-galactonate 5-dehydrogenase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate
 
 
 
 0.982
uxuR
Gntr family transcriptional regulator, uxu operon transcriptional repressor; Repressor for the uxuRBA operon
   
  
 0.878
exuR
Gntr family transcriptional regulator, hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers
   
  
 0.872
lgoT
Mfs transporter, acs family, l-galactonate transporter; Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L- galactonate as the sole carbon source
 
    0.792
uidR
Tetr/acrr family transcriptional regulator, repressor for uid operon; Repressor for the uidRABC (gusRABC) operon
      
 0.788
kdgR
Iclr family transcriptional regulator, kdg regulon repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease
   
  
 0.605
nrfB
Nitrite reductase, formate-dependent, penta-heme cytochrome c; Plays a role in nitrite reduction
  
     0.494
ecnA
Entericidin a membrane lipoprotein, antidote entericidin b; Acts as antidote to the effect of entericidin B
  
     0.484
abrB
Regulator of aidb expression; Seems to be involved in the regulation of AidB
  
     0.483
ydhT
annotation not available
  
     0.446
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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