node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
baeS | creB | b2078 | b4398 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | 0.849 |
baeS | rstB | b2078 | b1609 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Sensory histidine kinase of RstAB two-component system; Member of the two-component regulatory system RstB/RstA. RstB functions as a membrane-associated protein kinase that phosphorylates RstA (Probable). | 0.525 |
baeS | yedV | b2078 | b1968 | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR. | 0.460 |
basS | creB | b4112 | b4398 | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | 0.802 |
basS | zraS | b4112 | b4003 | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. | 0.778 |
creA | creB | b4397 | b4398 | Putative periplasmic protein. | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | 0.973 |
creA | creC | b4397 | b4399 | Putative periplasmic protein. | Sensory histidine kinase in two-component regulatory system with CreB or PhoB; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB. | 0.992 |
creA | creD | b4397 | b4400 | Putative periplasmic protein. | Inner membrane protein; Tolerance to colicin E2. | 0.914 |
creB | baeS | b4398 | b2078 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons. | 0.849 |
creB | basS | b4398 | b4112 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. | 0.802 |
creB | creA | b4398 | b4397 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Putative periplasmic protein. | 0.973 |
creB | creC | b4398 | b4399 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase in two-component regulatory system with CreB or PhoB; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB. | 0.999 |
creB | creD | b4398 | b4400 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Inner membrane protein; Tolerance to colicin E2. | 0.936 |
creB | cusS | b4398 | b0570 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. | 0.739 |
creB | phoR | b4398 | b0400 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | 0.783 |
creB | rstB | b4398 | b1609 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase of RstAB two-component system; Member of the two-component regulatory system RstB/RstA. RstB functions as a membrane-associated protein kinase that phosphorylates RstA (Probable). | 0.714 |
creB | yedV | b4398 | b1968 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via the redox state of the membrane. Activates HprR by phosphorylation. Can also phosphorylate CusR. | 0.820 |
creB | zraS | b4398 | b4003 | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. | 0.806 |
creC | creA | b4399 | b4397 | Sensory histidine kinase in two-component regulatory system with CreB or PhoB; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB. | Putative periplasmic protein. | 0.992 |
creC | creB | b4399 | b4398 | Sensory histidine kinase in two-component regulatory system with CreB or PhoB; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB. | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. | 0.999 |