STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ykfHBelongs to the YeeT/YkfH/YpjJ family (73 aa)    
Predicted Functional Partners:
yafX
Uncharacterized protein YafX; Phage or Prophage Related; Belongs to the antirestriction protein family
 
   
 0.995
yafW
Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YkfI . It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism . Co-overexpression of toxin YkfI and antitoxin YafW leads to formation of elongated cells .
 
  
 0.990
ykfF
UPF0401 protein YkfF; Phage or Prophage Related; Belongs to the UPF0401 family
 
  
 0.987
ykfG
Belongs to the UPF0758 family
   
 0.985
ykfI
Toxic component of a type IV toxin-antitoxin (TA) system . Acts as a toxin inhibitor that blocks cell division and cell elongation via FtsZ and possibly also MreB (although no interaction with MreB has been proven) . Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation (PubMed:14594833, PubMed:28257056, PubMed:28931012). These effects are overcome by concomitant expression of cognate antitoxin YafW, which leads to toxin loss by an unknown mechanism . Overexpression leads to formation of lemon-shaped cells and cell lysis; inactivated by ov [...]
 
   
 0.983
yfjX
Belongs to the antirestriction protein family.
 
  
 0.937
yfjZ
Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YpjF . Also counteracts the effect of non-cognate toxins CbtA and YfkI
 
   
 0.811
cbeA
Antitoxin component of a type IV toxin-antitoxin (TA) system . Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV) . It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles . The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes . The intergenic region was not found to be necessary in another study . Also counteracts the morphological defects caused by ove [...]
  
   
 0.809
cbtA
Toxic component of a type IV toxin-antitoxin (TA) system (PubMed:14594833, PubMed:21166897, PubMed:22515815, PubMed:28931012, PubMed:28257056). Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization (PubMed:21166897, PubMed:28931012). Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization and localization, leading to blockag [...]
 
   
 0.807
ypjF
Toxic component of a type IV toxin-antitoxin (TA) system . Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with FtsZ and MreB . Overexpression results in inhibition of growth in liquid cultures . Overexpression leads to formation of lemon-shaped cells; inactivated by overexpression of cognate antitoxin YfjZ but not when the 2 genes are coexpressed from the same plasmid . Also neutralized by overexpression of non-cognate antitoxins YafW and CbeA
  
   
 0.805
Your Current Organism:
Escherichia coli K12 MG1655
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli K12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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