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ctu-1 protein (Neurospora crassa) - STRING interaction network
"ctu-1" - Putative uncharacterized protein in Neurospora crassa
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ctu-1Putative uncharacterized protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (403 aa)    
Predicted Functional Partners:
ctu-2
Predicted protein; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (809 aa)
     
  0.963
urm-1
Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2- thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target [...] (116 aa)
       
  0.703
103E1.100
Imidazole glycerol phosphate synthase hisHF (553 aa)
   
 
  0.684
cel-1
Fatty acid synthase alpha subunit reductase (1864 aa)
   
   
  0.673
aro-1
Pentafunctional AROM polypeptide; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1563 aa)
     
 
  0.671
8D4.110
Probable histone acetyltransferase (571 aa)
     
 
  0.666
EFNCRP00000006866
Putative uncharacterized protein (1322 aa)
 
            0.626
EFNCRP00000005064
Putative uncharacterized protein (486 aa)
   
 
  0.499
B11O8.080
Probable IMP3 (Component of the U3 small nucleolar ribonucleoprotein) (183 aa)
   
   
  0.491
B14D6.350
Putative uncharacterized protein (642 aa)
   
 
  0.488
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 5141
Other names: Chrysonilia crassa, N. crassa, Neurospora, Neurospora crassa
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