STRINGSTRING
pan-2 protein (Neurospora crassa) - STRING interaction network
"pan-2" - PAB-dependent poly(A)-specific ribonuclease subunit pan-2 in Neurospora crassa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pan-2PAB-dependent poly(A)-specific ribonuclease subunit pan-2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein PAB1, which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome- mediated 3’-5’ exonucleolytic degradation, or deadenlyation- dependent mRNA decaping and subsequent 5’-3 [...] (1211 aa)    
Predicted Functional Partners:
EFNCRP00000001345
PAB-dependent poly(A)-specific ribonuclease subunit pan-3 (550 aa)
     
  0.999
B8J22.130
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (259 aa)
     
  0.818
EFNCRP00000004477
Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA (764 aa)
       
  0.710
EFNCRP00000001836
Ribosome biogenesis protein BRX1 (305 aa)
     
        0.695
ccr4
Glucose-repressible alcohol dehydrogenase transcriptional effector (786 aa)
     
 
  0.684
EFNCRP00000009624
Putative uncharacterized protein (200 aa)
     
      0.656
aro-1
Pentafunctional AROM polypeptide; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis (1563 aa)
         
  0.646
ytm-1
Ribosome biogenesis protein ytm-1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (487 aa)
     
        0.628
29E8.060
Putative uncharacterized protein (469 aa)
     
        0.622
EFNCRP00000008633
Putative uncharacterized protein (341 aa)
     
      0.599
Your Current Organism:
Neurospora crassa
NCBI taxonomy Id: 5141
Other names: Chrysonilia crassa, N. crassa, Neurospora, Neurospora crassa
Server load: low (8%) [HD]