STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (216 aa)    
Predicted Functional Partners:
hisZ
histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.997
hisI
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
 
  
 0.995
hisB
Psort-B: Cytoplasmic, score:8.87; COG0131 Imidazoleglycerol-phosphate dehydratase; HMMPfam:IPR000807; BlastProDom:IPR000807; HMMPanther:IPR000807; ScanRegExp:IPR000807; K01693 imidazoleglycerol-phosphate dehydratase.
 
  
 0.995
hisF
Cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.990
hisH
Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.986
ACR71565.1
histidyl-tRNA synthetase; Psort-B: Cytoplasmic, score:10.00; COG0124 Histidyl-tRNA synthetase; HMMPfam:IPR002314; HMMPIR:IPR004516; HMMPanther:IPR015805; K01891 histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.928
hisC
Psort-B: Cytoplasmic, score:8.87; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HMMPfam:IPR004839; Gene3D:IPR015421; Gene3D:IPR015422; HMMTigr:IPR005861; ScanRegExp:IPR001917; superfamily:IPR015424; K00817 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.857
ACR72911.1
Ribose-phosphate pyrophosphokinase; Psort-B: Unknown cell location; COG0462 Phosphoribosylpyrophosphate synthetase; HMMPfam:IPR000836; HMMTigr:IPR005946; ScanRegExp:IPR002375; K00948 ribose-phosphate pyrophosphokinase.
  
 
 0.852
ACR71148.1
Threonine-phosphate decarboxylase; Psort-B: Cytoplasmic, score:8.87; COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes; HMMPfam:IPR004839; HMMPfam:IPR005835; FPrintScan:IPR001176; Gene3D:IPR015421; ScanRegExp:IPR004838; superfamily:IPR015424; K04720 threonine-phosphate decarboxylase.
  
  
 0.799
Your Current Organism:
Eubacterium eligens
NCBI taxonomy Id: 515620
Other names: Eubacterium eligens ATCC 27750, [. eligens ATCC 27750, [Eubacterium] eligens ATCC 27750
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.