node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpar_0560 | Cpar_1875 | Cpar_0560 | Cpar_1875 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | 0.999 |
Cpar_0560 | Cpar_1876 | Cpar_0560 | Cpar_1876 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: pvi:Cvib_1598 2-oxoglutarate ferredoxin oxidoreductase subunit beta. | 0.999 |
Cpar_0560 | gcvH | Cpar_0560 | Cpar_0562 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.434 |
Cpar_0560 | gcvPA | Cpar_0560 | Cpar_0563 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.524 |
Cpar_0560 | glyA | Cpar_0560 | Cpar_1518 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.692 |
Cpar_0560 | lpd | Cpar_0560 | Cpar_0724 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.944 |
Cpar_0560 | prs | Cpar_0560 | Cpar_0796 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.473 |
Cpar_0814 | gcvH | Cpar_0814 | Cpar_0562 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.978 |
Cpar_0814 | gcvPA | Cpar_0814 | Cpar_0563 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.435 |
Cpar_0814 | gcvPB | Cpar_0814 | Cpar_0121 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.427 |
Cpar_0814 | gcvT | Cpar_0814 | Cpar_0418 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.470 |
Cpar_0814 | lpd | Cpar_0814 | Cpar_0724 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.895 |
Cpar_0814 | prs | Cpar_0814 | Cpar_0796 | PFAM: biotin/lipoate A/B protein ligase; KEGG: cte:CT1342 lipoate-protein ligase A, putative. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.821 |
Cpar_1875 | Cpar_0560 | Cpar_1875 | Cpar_0560 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | 0.999 |
Cpar_1875 | Cpar_1876 | Cpar_1875 | Cpar_1876 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: pvi:Cvib_1598 2-oxoglutarate ferredoxin oxidoreductase subunit beta. | 0.999 |
Cpar_1875 | glyA | Cpar_1875 | Cpar_1518 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.405 |
Cpar_1875 | lpd | Cpar_1875 | Cpar_0724 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.923 |
Cpar_1876 | Cpar_0560 | Cpar_1876 | Cpar_0560 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: pvi:Cvib_1598 2-oxoglutarate ferredoxin oxidoreductase subunit beta. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cte:CT1628 pyruvate flavodoxin/ferrodoxin oxidoreductase. | 0.999 |
Cpar_1876 | Cpar_1875 | Cpar_1876 | Cpar_1875 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: pvi:Cvib_1598 2-oxoglutarate ferredoxin oxidoreductase subunit beta. | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: pvi:Cvib_1597 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. | 0.999 |
Cpar_1876 | lpd | Cpar_1876 | Cpar_0724 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: pvi:Cvib_1598 2-oxoglutarate ferredoxin oxidoreductase subunit beta. | Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.907 |