node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cpar_1246 | Cpar_1992 | Cpar_1246 | Cpar_1992 | PFAM: aminotransferase class I and II; KEGG: cte:CT0966 aspartate aminotransferase, putative. | PFAM: Prephenate dehydrogenase; KEGG: cte:CT0084 prephenate dehydrogenase. | 0.914 |
Cpar_1246 | hisC | Cpar_1246 | Cpar_1261 | PFAM: aminotransferase class I and II; KEGG: cte:CT0966 aspartate aminotransferase, putative. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.915 |
Cpar_1246 | pheA | Cpar_1246 | Cpar_0524 | PFAM: aminotransferase class I and II; KEGG: cte:CT0966 aspartate aminotransferase, putative. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: cte:CT1666 prephenate dehydratase. | 0.990 |
Cpar_1992 | Cpar_1246 | Cpar_1992 | Cpar_1246 | PFAM: Prephenate dehydrogenase; KEGG: cte:CT0084 prephenate dehydrogenase. | PFAM: aminotransferase class I and II; KEGG: cte:CT0966 aspartate aminotransferase, putative. | 0.914 |
Cpar_1992 | hisC | Cpar_1992 | Cpar_1261 | PFAM: Prephenate dehydrogenase; KEGG: cte:CT0084 prephenate dehydrogenase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.971 |
Cpar_1992 | pheA | Cpar_1992 | Cpar_0524 | PFAM: Prephenate dehydrogenase; KEGG: cte:CT0084 prephenate dehydrogenase. | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: cte:CT1666 prephenate dehydratase. | 0.945 |
hisA | hisB | Cpar_0471 | Cpar_0701 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | 0.986 |
hisA | hisC | Cpar_0471 | Cpar_1261 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.931 |
hisA | hisD | Cpar_0471 | Cpar_1440 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
hisA | hisF | Cpar_0471 | Cpar_1605 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Cpar_0471 | Cpar_0247 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.955 |
hisA | hisH | Cpar_0471 | Cpar_0470 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Cpar_0471 | Cpar_0458 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | Cpar_0701 | Cpar_0471 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: cte:CT0477 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.986 |
hisB | hisC | Cpar_0701 | Cpar_1261 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: cte:CT1256 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Cpar_0701 | Cpar_1440 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | Cpar_0701 | Cpar_1605 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisB | hisG | Cpar_0701 | Cpar_0247 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.976 |
hisB | hisH | Cpar_0701 | Cpar_0470 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisB | hisI | Cpar_0701 | Cpar_0458 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: cte:CT0735 imidazoleglycerol-phosphate dehydratase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.987 |